论文标题

从神经元模拟中计算细胞外电势

Computing extracellular electric potentials from neuronal simulations

论文作者

Ness, Torbjørn V., Halnes, Geir, Næss, Solveig, Pettersen, Klas H., Einevoll, Gaute T.

论文摘要

在近一个世纪中,神经活动中电位的测量在神经科学中起着关键作用,神经活动的模拟是理解此类测量的重要工具。体积导体(VC)理论用于计算细胞外电势,例如细胞外尖峰,MUA,LFP,ECOG,ECOG和周围神经元周围的EEG,以及反相反,以通过电流源密度方法从记录的电位中重建来自记录的电位的神经元电流源分布。在本书章节中,我们展示了如何从细胞外介质中的离子浓度动力学的详细电源理论得出,并展示必须引入哪些假设才能在神经科学家通常使用的简化形式上获取VC理论。此外,我们提供了如何将理论应用于神经元和神经元种群产生的峰值,LFP信号和脑电图信号的示例。

Measurements of electric potentials from neural activity have played a key role in neuroscience for almost a century, and simulations of neural activity is an important tool for understanding such measurements. Volume conductor (VC) theory is used to compute extracellular electric potentials such as extracellular spikes, MUA, LFP, ECoG and EEG surrounding neurons, and also inversely, to reconstruct neuronal current source distributions from recorded potentials through current source density methods. In this book chapter, we show how VC theory can be derived from a detailed electrodiffusive theory for ion concentration dynamics in the extracellular medium, and show what assumptions that must be introduced to get the VC theory on the simplified form that is commonly used by neuroscientists. Furthermore, we provide examples of how the theory is applied to compute spikes, LFP signals and EEG signals generated by neurons and neuronal populations.

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