论文标题
动态组织上细胞命运选择的数学模型
A mathematical model of cell fate selection on a dynamic tissue
论文作者
论文摘要
多细胞组织是许多生物系统和器官的基础。这些组织不是静态的，而是随着时间的推移动态变化。即使整体结构保持不变，组织内部也存在细胞的营业额。这种动态的体内平衡是通过众多管理机制来维持的，这些机制的调谐方式使组织保持稳态状态，即使在大型时间表上也是如此。这些管理机制中的一些包括细胞运动和通过细胞间信号传导选择细胞命运。但是，尚不清楚如何将这两个过程联系起来，或者它们如何在整个组织中相互影响。在本文中，我们提出了一个多细胞多尺度模型，该模型将细胞运动的两种现象和细胞间信号传导汇总在一起，以描述动态组织上的细胞命运选择。我们发现，对细胞信号传导的亲和力极大地影响了细胞分化的能力。我们还发现，我们的结果支持声称细胞分化是稳态的动态组织中的一个细微调整的过程，其细胞周转率过多导致不健康（未分化和不公平）组织。
Multicellular tissues are the building blocks of many biological systems and organs. These tissues are not static, but dynamically change over time. Even if the overall structure remains the same there is a turnover of cells within the tissue. This dynamic homeostasis is maintained by numerous governing mechanisms which are finely tuned in such a way that the tissue remains in a homeostatic state, even across large timescales. Some of these governing mechanisms include cell motion, and cell fate selection through inter cellular signalling. However, it is not yet clear how to link these two processes, or how they may affect one another across the tissue. In this paper, we present a multicellular, multiscale model, which brings together the two phenomena of cell motility, and inter cellular signalling, to describe cell fate selection on a dynamic tissue. We find that the affinity for cellular signalling to occur greatly influences a cells ability to differentiate. We also find that our results support claims that cell differentiation is a finely tuned process within dynamic tissues at homeostasis, with excessive cell turnover rates leading to unhealthy (undifferentiated and unpatterned) tissues.
