论文标题

转座元件的动力学在遗传序列中产生结构和对称性

Dynamics of transposable elements generates structure and symmetries in genetic sequences

论文作者

Cristadoro, Giampaolo, Esposti, Mirko Degli, Altmann, Eduardo G.

论文摘要

已知遗传序列具有非平凡的组成以及其成分频率的对称性。最近,已经表明,对称性和结构在DNA中层次相互交织,这表明这两个特征都是共同的起源。但是,导致这种关系的机制尚不清楚。在这里,我们研究了遗传序列进化的生物学动机动力学。我们表明,出现了亚稳态(长期)的状态,其中序列具有对称性和结构的结构,以与现有基因组相匹配的方式。

Genetic sequences are known to possess non-trivial composition together with symmetries in the frequencies of their components. Recently, it has been shown that symmetry and structure are hierarchically intertwined in DNA, suggesting a common origin for both features. However, the mechanism leading to this relationship is unknown. Here we investigate a biologically motivated dynamics for the evolution of genetic sequences. We show that a metastable (long-lived) regime emerges in which sequences have symmetry and structure interlaced in a way that matches that of extant genomes.

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