论文标题
生命生命生物消耗生命的能源消耗的普遍关系：衰老起源的见解
Universal Relation for Life-span Energy Consumption in Living Organisms: Insights for the origin of ageing
论文作者
论文摘要
长期以来，人们一直认为代谢能量消耗在衰老过程中起着重要作用（{\ it 1}）。在整个物种之间，一克的组织平均消耗在生命跨度（{\ it 2}）期间大约相同的能量。能量限制还显示出增加最大寿命（{\ it 3}）并阻碍与年龄相关的变化（{\ it 4}）。但是，在生命中，普遍的能源消耗有明显的例外，主要来自阶层间比较（{\ it 5，6}）。在这里，我们提出了一种独特的关系，可用于生命跨度能源消耗，有效期为$ \ sim $ 300，代表所有类别的生物体，从单细胞生物到最大的哺乳动物。该关系的平均分散仅为0.3 dex，其中有95 \％（$ \ rm 2-σ$）的生物体的出发率小于$π$，尽管$ \ sim $ \ sim $ \ sim $ 20 $ 20的体重差异差异，但仅降低了仅与几何因素相关的任何可能的阶段变化。 This result can be interpreted as supporting evidence for the existence of an approximately constant total number $\rm N_r \sim 10^8$ of respiration cycles per lifetime for all organisms, effectively predetermining the extension of life by the basic energetics of respiration, being an incentive for future studies that investigate the relation of such constant $\rm N_r$ cycles per lifetime with the production rates of free radicals and氧化剂可能会对衰老的起源产生明确的约束。
Metabolic energy consumption has long been thought to play a major role in the aging process ({\it 1}). Across species, a gram of tissue on average expends about the same amount of energy during life-span ({\it 2}). Energy restriction has also been shown that increases maximum life-span ({\it 3}) and retards age-associated changes ({\it 4}). However, there are significant exceptions to a universal energy consumption during life-span, mainly coming from the inter-class comparison ({\it 5, 6}). Here we present a unique relation for life-span energy consumption, valid for $\sim$300 species representing all classes of living organisms, from unicellular ones to the largest mammals. The relation has an average scatter of only 0.3 dex, with 95\% ($\rm 2-σ$) of the organisms having departures less than a factor of $π$ from the relation, despite the $\sim$20 orders of magnitude difference in body mass, reducing any possible inter-class variation in the relation to only a geometrical factor. This result can be interpreted as supporting evidence for the existence of an approximately constant total number $\rm N_r \sim 10^8$ of respiration cycles per lifetime for all organisms, effectively predetermining the extension of life by the basic energetics of respiration, being an incentive for future studies that investigate the relation of such constant $\rm N_r$ cycles per lifetime with the production rates of free radicals and oxidants, which may give definite constraints on the origin of ageing.
