论文标题

在多组分液体混合物中设计分离相的形态

Designing morphology of separated phases in multicomponent liquid mixtures

论文作者

Mao, Sheng, Chakraverti-Wuerthwein, Milena S., Gaudio, Hunter, Kosmrlj, Andrej

论文摘要

多组分液体混合物的相位分离在从行业到细胞生物学的许多过程中起着不可或缺的作用。在许多情况下,共存阶段的形态与分离的混合物的功能至关重要,但是目前尚不清楚是什么决定了何时存在多个阶段的形态。我们开发了一种图理论方法,以预测给定的表面能量(正向问题),列举所有拓扑上不同的形态以及对产生目标形态(反问题)的表面能量的反向工程条件进行预测的阶段拓扑。

Phase separation of multicomponent liquid mixtures plays an integral part in many processes ranging from industry to cellular biology. In many cases the morphology of coexisting phases is crucially linked to the function of the separated mixture, yet it is unclear what determines morphology when multiple phases are present. We developed a graph theory approach to predict the topology of coexisting phases from a given set of surface energies (forward problem), enumerate all topologically distinct morphologies, and reverse engineer conditions for surface energies that produce the target morphology (inverse problem).

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