论文标题
合并1D和3D基因组信息：建模和验证方面的挑战
Merging 1D and 3D genomic information: Challenges in modelling and validation
论文作者
论文摘要
相互作用期间真核生物中的基因组组织源于DNA多核苷酸线性序列中存在的非随机相关性与物理/化学反应之间的微妙平衡，这些核苷酸线性序列和物理/化学反应连续形成了细胞核内DNA和染色质的形式和结构。现在很明显，这些机制在基因调节等重要过程中具有关键作用，但是它们同时行动的详细方式，最终，即使在截然不同的长度尺度上，它们甚至在很大程度上都没有探索。在本文中，我们概括了有关基因调节和物理机制的一些主要结果，与1D序列中编码的信息以及DNA的3D折叠结构有关。特别是，我们强调了1D和3D模型之间的相互交叉进食如何提供有关这些复杂过程如何相互工作和影响彼此的原始见解。
Genome organization in eukaryotes during interphase stems from the delicate balance between non-random correlations present in the DNA polynucleotide linear sequence and the physico/chemical reactions which shape continuously the form and structure of DNA and chromatin inside the nucleus of the cell. It is now clear that these mechanisms have a key role in important processes like gene regulation, yet the detailed ways they act simultaneously and, eventually, come to influence each other even across very different length-scales remain largely unexplored. In this paper, we recapitulate some of the main results concerning gene regulatory and physical mechanisms, in relation to the information encoded in the 1D sequence and the 3D folding structure of DNA. In particular, we stress how reciprocal crossfeeding between 1D and 3D models may provide original insight into how these complex processes work and influence each other.
