论文标题
Parylene Photonics：一个具有柔性的，宽带光学波导平台，具有集成的微ror剂量的生物界面
Parylene Photonics: A Flexible, Broadband Optical Waveguide Platform with Integrated Micromirrors for Biointerfaces
论文作者
论文摘要
在诸如大脑的光遗传刺激以及组织的体内功能或结构成像等应用中，需要靶向的光递送到生物组织中。这些应用需要非常紧凑，柔软和柔性的植入物，以最大程度地减少对组织的损害。 Here, we demonstrate a novel implantable photonic platform based on a high-density, flexible array of ultracompact (30 $μ$m x 5 $μ$m), low-loss (3.2 dB/cm at $λ$ = 680 nm, 4.1 dB/cm at $λ$ = 633 nm, 4.9 dB/cm at $λ$ = 532 nm, 6.1 dB/cm at $λ$ = 450 nm）由生物相容性聚合物Parylene C和聚二甲基硅氧烷（PDMS）制成的光学波导。这个光子平台具有独特的嵌入式输入/输出微型摩擦剂，可将光线从垂直于阵列表面的波导中重定向，以用于组织中的局部图案照明。该体系结构可以设计一个完全柔韧，紧凑的集成光子系统，用于诸如体内慢性遗传学刺激大脑活性之类的应用。
Targeted light delivery into biological tissue is needed in applications such as optogenetic stimulation of the brain and in vivo functional or structural imaging of tissue. These applications require very compact, soft, and flexible implants that minimize damage to tissue. Here, we demonstrate a novel implantable photonic platform based on a high-density, flexible array of ultracompact (30 $μ$m x 5 $μ$m), low-loss (3.2 dB/cm at $λ$ = 680 nm, 4.1 dB/cm at $λ$ = 633 nm, 4.9 dB/cm at $λ$ = 532 nm, 6.1 dB/cm at $λ$ = 450 nm) optical waveguides made of biocompatible polymers Parylene C and polydimethylsiloxane (PDMS). This photonic platform features unique embedded input/output micro-mirrors that redirect light from the waveguides perpendicularly to the surface of the array for localized, patterned illumination in tissue. This architecture enables the design of a fully flexible, compact integrated photonic system for applications such as in vivo chronic optogenetic stimulation of brain activity.
