论文标题
自然种群中的基因驱动动力学：密度依赖，空间和性别的重要性
Gene drive dynamics in natural populations: The importance of density-dependence, space and sex
论文作者
论文摘要
合成基因驱动器的传播经常在通过基因流量连接并用简单确定性模型描述的杂种种群的背景下进行讨论。在这样的假设下，可以通过释放一个携带侵入性基因驱动器（例如标准归巢驱动器）的单个个体来改变整个物种。尽管这仍然是一种理论上的可能性，但自然种群中的基因驱动扩散更为复杂，值得更现实的评估。在人群中释放的任何基因驱动器的命运都将与人口的生态有密密联系。鉴于经常在自然种群的生态评估中涉及的不确定性，因此了解基因驱动的敏感性扩散到重要的生态因素至关重要。在这里，我们回顾了不同形式的密度依赖性，空间异质性和交配行为如何影响自我维持基因驱动器的传播。我们重点介绍了基因驱动动力学的特定方面和需要进一步研究的目标种群。
The spread of synthetic gene drives is often discussed in the context of panmictic populations connected by gene flow and described with simple deterministic models. Under such assumptions, an entire species could be altered by releasing a single individual carrying an invasive gene drive, such as a standard homing drive. While this remains a theoretical possibility, gene drive spread in natural populations is more complex and merits a more realistic assessment. The fate of any gene drive released in a population would be inextricably linked to the ecology of the population. Given the uncertainty often involved in ecological assessment of natural populations, understanding the sensitivity of gene drive spread to important ecological factors is critical. Here we review how different forms of density-dependence, spatial heterogeneity and mating behaviors can impact the spread of self-sustaining gene drives. We highlight specific aspects of gene drive dynamics and the target populations that need further research.
