论文标题
使用纤维弯曲产生的斑点，以改善无透镜微镜检查中的工作距离和背景拒绝
Using fiber-bending generated speckles for improved working distance and background-rejection in lensless microendoscopy
论文作者
论文摘要
无透镜柔性纤维 - 基于纤维 - 内窥镜可以在超出传统显微镜范围内的深度成像，其足迹最小。当目标与纤维相邻时，这些多层纤维为广场荧光成像提供了简单的解决方案。但是，他们的工作距离非常有限，并且焦点背景。在这里，我们仔细研究了通过弯曲商业纤维束产生的动态斑点照明模式，并证明它们可以使用多个帧的超分辨率波动成像（SOFI）分析，以允许扩展工作距离和背景排斥，而无需添加任何光学元素。
Lensless flexible fiber-bundle based endoscopes allow imaging at depths beyond the reach of conventional microscopes with a minimal footprint. These multicore fibers provide a simple solution for widefield fluorescent imaging when the target is adjacent to the fiber facet. However, they suffer from a very limited working distance and out-of-focus background. Here, we carefully study the dynamic speckle illumination patterns generated by bending a commercial fiber-bundle, and show that they can be exploited to allow extended working distance and background rejection, using a super-resolution fluctuations imaging (SOFI) analysis of multiple frames, without the addition of any optical elements.
