论文标题
从五分钟的扫描中完全自明的全心4D流量成像
Fully Self-Gated Whole-Heart 4D Flow Imaging from a Five-Minute Scan
论文作者
论文摘要
目的：开发和验证一种采集和处理技术，该技术可以在固定的五分钟扫描中进行全心覆盖的完全自我控制的4D流成像。 理论和方法：使用笛卡尔采样连续获取数据，并使用自门信号分类为呼吸道和心脏箱。重建是使用最近提出的称为Replay4D的贝叶斯方法进行的。使用来自八名健康志愿者和两名患者的数据来验证4D，并与压缩感测技术L1 sense进行了比较。 结果：健康受试者 - 与2D相对比度MRI（2D-PC）相比，揭示4D的流量定量没有明显的偏差。相比之下，L1-Sense的峰值速度和峰值流速被显着低估。与传统的基于MRI的4D流量成像相比，Replay4D表现出净流量和峰值流量的较小但显着的偏见，峰值速度没有明显的偏差。所有这三个指数都被L1-Sense明显低估了。患者 - 揭示4D的流量定量与2D-PC参考非常吻合。相比之下，L1态明显低估了峰值速度。 结论：高度加速的五分钟笛卡尔采集，自我门控和揭示4D的组合可以使全心4D流量成像具有准确的流量定量。
Purpose: To develop and validate an acquisition and processing technique that enables fully self-gated 4D flow imaging with whole-heart coverage in a fixed five-minute scan. Theory and Methods: The data are acquired continuously using Cartesian sampling and sorted into respiratory and cardiac bins using the self-gating signal. The reconstruction is performed using a recently proposed Bayesian method called ReVEAL4D. ReVEAL4D is validated using data from eight healthy volunteers and two patients and compared with a compressed sensing technique, L1-SENSE. Results: Healthy subjects -- Compared to 2D phase-contrast MRI (2D-PC), flow quantification from ReVEAL4D shows no significant bias. In contrast, the peak velocity and peak flow rate for L1-SENSE are significantly underestimated. Compared to traditional parallel MRI-based 4D flow imaging, ReVEAL4D demonstrates small but significant biases in net flow and peak flow rate, with no significant bias in peak velocity. All three indices are significantly and more markedly underestimated by L1-SENSE. Patients -- Flow quantification from ReVEAL4D agrees well with the 2D-PC reference. In contrast, L1-SENSE markedly underestimated peak velocity. Conclusions: The combination of highly accelerated five-minute Cartesian acquisition, self-gating, and ReVEAL4D enables whole-heart 4D flow imaging with accurate flow quantification.
