论文标题
polylinkr：一种链接敏感的基因集富集r包装
PolyLinkR: A linkage-sensitive gene set enrichment R package
论文作者
论文摘要
我们介绍了Polylinkr，这是一种用于基因集富集分析的R包，它实现了一种新型的无效模型，该模型解释了属于同一基因集的基因之间的连锁不平衡 - 一种可能在相似工具中无法控制的假阳性的潜在原因。我们的基准表明，与两种类似的工具相比，Polylinkr的性能提高了，具有可比较的功率来检测富集基因集，同时平均产生少于一个错误检测到的基因，即使在高遗传聚类水平和名义假发现率也为20％。
We introduce PolyLinkR, an R package for gene set enrichment analysis that implements a novel null-model that accounts for linkage disequilibrium between genes belonging to the same gene set - a potential cause of false positives that is often not controlled for in similar tools. Our benchmarks show that PolyLinkR has improved performance compared to two similar tools, achieving comparable power to detect enriched gene sets while producing less than one falsely detected gene set on average, even at high genetic clustering levels and nominal false discovery rates of 20%.
