论文标题
生物化学反应网络中功能突变的增益和丧失：一种用于结直肠癌细胞应用的数学模型
Gain and Loss of Function mutations in biological chemical reaction networks: a mathematical model with application to colorectal cancer cells
论文作者
论文摘要
本文研究了建模化学反应网络的普通微分方程系统的系统，并从中衍生出一种模拟工具，模仿了功能丧失和癌细胞中功能突变的增益。更具体地说，从理论的角度来看，我们的方法着重于确定系统的部分保护定律及其与相应的化学计量表面的关系。然后，我们表明，可以通过修改系统中的初始条件在模型中实现功能突变的丧失，而功能突变的增益可以通过消除特定反应来实现。最后，该模型用于详细检查结直肠癌细胞的G1-S期。
This paper studies a system of Ordinary Differential Equations modeling a chemical reaction network and derives from it a simulation tool mimicking Loss of Function and Gain of Function mutations found in cancer cells. More specifically, from a theoretical perspective, our approach focuses on the determination of moiety conservation laws for the system and their relation with the corresponding stoichiometric surfaces. Then we show that Loss of Function mutations can be implemented in the model via modification of the initial conditions in the system, while Gain of Function mutations can be implemented by eliminating specific reactions. Finally, the model is utilized to examine in detail the G1-S phase of a colorectal cancer cell.
