论文标题
弯曲场光学相干断层扫描：人角膜细胞和神经的大视野成像
Curved-field optical coherence tomography: large-field imaging of human corneal cells and nerves
论文作者
论文摘要
高分辨率光学成像方法，例如共聚焦显微镜和全场光学相干断层扫描，捕获样品的平坦光学片段。如果样品是弯曲的，则通过几个样品层的光场截面，并且每层的视图都会降低。在这里，我们介绍曲线光学相干断层扫描，能够捕获任意曲率的光学部分。我们测试了该设备的挑战性任务，即与临床最先进的体内成像体内角膜并达到10倍更大的观察区域。这使得更精确的细胞和神经计数，为改善角膜和一般健康状况的诊断（例如糖尿病）开辟了道路。该方法是非接触，紧凑的，并且可以单发工作，因此可以轻松地用于光学研究和临床实践。
High-resolution optical imaging methods, such as confocal microscopy and full-field optical coherence tomography, capture flat optical sections of the sample. If the sample is curved, the optical field sections through several sample layers and the view of each layer is reduced. Here we present curved-field optical coherence tomography, capable of capturing optical sections of arbitrary curvature. We test the device on a challenging task of imaging the human cornea in vivo and achieve 10x larger viewing area comparing to the clinical state-of-the-art. This enables more precise cell and nerve counts, opening a path to improved diagnosis of corneal and general health conditions (e.g. diabetes). The method is non-contact, compact and works in a single-shot, making it readily available for use in optical research and clinical practice.
