论文标题
柔性时间分辨率的MR血管造影的无监督深度学习
Unsupervised Deep Learning for MR Angiography with Flexible Temporal Resolution
论文作者
论文摘要
由于其高度加速的采集,时间分辨MR血管造影(TMRA)已被广泛用于动态对比度增强MRI(DCE-MRI)。在TMRA中,对K空间数据的外围进行了稀疏采样,以便可以合并相邻的帧以构建一个时间框架。但是,该视图共享计划从根本上限制了时间分辨率,并且不可能更改视图共享数字以实现不同的时空解决方案权衡。尽管最近已经提出了从稀疏样本重建的MR重建的许多深度学习方法,但现有方法通常需要匹配的完全采样的K空间参考数据以进行监督培训,这不适合TMRA。这是因为高时空分辨率的地面真相图像不适合TMRA。为了解决这个问题,我们在这里提出了一种新颖的无监督深度学习,使用最佳运输驱动的循环偶然的生成对抗网络(Cyclegan)。与传统的自行车结构使用两对发电机和歧视器相反,新的体系结构仅需要一对生成器和歧视器,这使得训练变得更加简单并改善了性能。使用体内TMRA数据集的重建结果确认,该方法可以立即以各种视图共享数量选择产生高质量的重建结果,从而使我们能够在时间分辨的MR血管造影中利用空间和时间分辨率之间的更好折衷。
Time-resolved MR angiography (tMRA) has been widely used for dynamic contrast enhanced MRI (DCE-MRI) due to its highly accelerated acquisition. In tMRA, the periphery of the k-space data are sparsely sampled so that neighbouring frames can be merged to construct one temporal frame. However, this view-sharing scheme fundamentally limits the temporal resolution, and it is not possible to change the view-sharing number to achieve different spatio-temporal resolution trade-off. Although many deep learning approaches have been recently proposed for MR reconstruction from sparse samples, the existing approaches usually require matched fully sampled k-space reference data for supervised training, which is not suitable for tMRA. This is because high spatio-temporal resolution ground-truth images are not available for tMRA. To address this problem, here we propose a novel unsupervised deep learning using optimal transport driven cycle-consistent generative adversarial network (cycleGAN). In contrast to the conventional cycleGAN with two pairs of generator and discriminator, the new architecture requires just a single pair of generator and discriminator, which makes the training much simpler and improves the performance. Reconstruction results using in vivo tMRA data set confirm that the proposed method can immediately generate high quality reconstruction results at various choices of view-sharing numbers, allowing us to exploit better trade-off between spatial and temporal resolution in time-resolved MR angiography.