论文标题

SARS-COV-2(COVID-19)按数字

SARS-CoV-2 (COVID-19) by the numbers

论文作者

Bar-On, Yinon M., Flamholz, Avi I., Phillips, Rob, Milo, Ron

论文摘要

当前的SARS-COV-2大流行是一种苛刻的提醒,即,无论是在一个人的单一人类宿主还是在各大洲的一波感染中,病毒动态通常都是关于数字的故事。在此快照中,我们的目的是为关键数字提供一站式的图形源,以帮助我们了解驱动当前全球危机的病毒。讨论围绕两个广泛的主题进行了构建:1)病毒本身的生物学以及2)单个人类宿主感染的特征。我们的一页摘要提供了与SARS-COV-2有关的关键数字,主要基于经过同行评审的文献。以下注释的参考文献证实了以摘要格式报告的数字。敦促读者记住,仍然存在许多不确定性以及对这种大流行的知识以及驱动其迅速发展的病毒。在下面的段落中,我们提供了“信封的背面”计算,这些计算说明了从了解一些关键数字和使用定量逻辑中获得的见解。这些计算是通过理智检查改善我们的直觉,但不能取代详细的流行病学分析。

The current SARS-CoV-2 pandemic is a harsh reminder of the fact that, whether in a single human host or a wave of infection across continents, viral dynamics is often a story about the numbers. In this snapshot, our aim is to provide a one-stop, curated graphical source for the key numbers that help us understand the virus driving our current global crisis. The discussion is framed around two broad themes: 1) the biology of the virus itself and 2) the characteristics of the infection of a single human host. Our one-page summary provides the key numbers pertaining to SARS-CoV-2, based mostly on peer-reviewed literature. The numbers reported in summary format are substantiated by the annotated references below. Readers are urged to remember that much uncertainty remains and knowledge of this pandemic and the virus driving it is rapidly evolving. In the paragraphs below we provide "back of the envelope" calculations that exemplify the insights that can be gained from knowing some key numbers and using quantitative logic. These calculations serve to improve our intuition through sanity checks, but do not replace detailed epidemiological analysis.

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