论文标题
红外化学成像通过硅基摄像机中的非化学两光子吸收
Infrared chemical imaging through nondegenerate two-photon absorption in silicon-based cameras
论文作者
论文摘要
基于中红外（MIR）光谱对比的化学成像是一项重要技术，具有无数的应用，包括生物医学成像和环境监测。但是，与成熟的基于SI的设备相比，当前的mir摄像头缺乏性能，并且在可见的和近红外工作的设备的价格要低得多。在这里，我们通过标准的基于SI的电荷耦合器件（CCD）中的非分类两光吸收（NTA）证明了快速的miR化学成像。我们表明，可以在100毫秒的暴露时间使用picsecond脉冲能量通过NTA直接在CCD芯片上的NTA获得宽场miR图像。因为这种片上的方法不依赖相匹配，所以它是不带对齐的，并且不需要对图像进行复杂的后处理。我们通过对聚合物和生物样品的化学选择性miR成像（包括移动靶标，物理过程和活线虫的MIR视频）来强调该技术的实用性。
Chemical imaging based on mid-infrared (MIR) spectroscopic contrast is an important technique with a myriad of applications, including biomedical imaging and environmental monitoring. Current MIR cameras, however, lack in performance and are much less affordable compared to mature Si-based devices, which operate in the visible and near-infrared. Here we demonstrate fast MIR chemical imaging through non-degenerate two-photon absorption (NTA) in a standard Si-based charge-coupled device (CCD). We show that wide-field MIR images can be obtained at 100 ms exposure times using picosecond pulse energies of only a few fJ per pixel through NTA directly on the CCD chip. Because this on-chip approach does not rely on phase-matching, it is alignment-free and does not necessitate complex post-processing of the images. We emphasize the utility of this technique through chemically selective MIR imaging of polymers and biological samples, including MIR videos of moving targets, physical processes and live nematodes.
