论文标题
Sudr+K的双稳定性流行和测试试剂盒应用于Covid-19
Bi-stability of SUDR+K model of epidemics and test kits applied to COVID-19
论文作者
论文摘要
以世界政府对Covid-19的各种反应的动机,我们在这里开发了一个玩具模型,涉及依赖性流行病,该模型扩散在疾病的可用性上。我们称为Sudr+K的模型基于通常的SIR模型,但它将被感染个体的总比例分为两个组成部分:未被发现的组件以及通过测试检测到的组件。此外,我们认为可用的测试从流行病开始时以恒定的速度增加,但被食用以检测受感染的个体。令人惊讶的是,我们发现具有巨大的感染分数的相位和较小分数的相位之间的双稳定行为。我们表明,这两个制度之间的分离受测试率与在给定时间的感染率之间的匹配。我们还表明,两个阶段的存在并不取决于描述未检测到和检测到未检测到的个体的术语形式的数学选择。提出的研究表明,在流行病进入其巨大阶段之前,有剧烈的早期测试活动可能会控制流行病,即使测试速率的变化也很小,也可以增加或减少各种规模的整个流行病的大小。对于实际应用现实模型到正在进行的流行病中,我们很乐意与现场流行病学家合作,以开发测试过程的定量模型。
Motivated with various responses of world governments to COVID-19, here we develop a toy model of the dependence epidemics spreading on the availability of tests for disease. Our model, that we call SUDR+K, is based on usual SIR model, but it splits the total fraction of infected individuals into two components: those that are undetected and those that are detected through tests. Moreover, we assume that available tests increase at a constant rate from the beginning of epidemics but are consumed to detect infected individuals. Strikingly we find a bi-stable behavior between a phase with a giant fraction of infected and a phase with a very small fraction. We show that the separation between these two regimes is governed by a match between the rate of testing and a rate of infection spread at given time. We also show that the existence of two phases does not depend on the mathematical choice of the form of the term describing the rate at which undetected individuals are tested and detected. Presented research implies that a vigorous early testing activity, before the epidemics enters into its giant phase, can potentially keep epidemics under control, and that even a very small change in rate of testing can increase or decrease the size of the whole epidemics of various orders of magnitude. For the real application of realistic model to ongoing epidemics, we would gladly collaborate with field epidemiologists in order to develop quantitative models of testing process.