论文标题
在一类非本地相位模型的肿瘤生长模型上,具有奇异电位,趋化性和主动转运
On a class of non-local phase-field models for tumor growth with possibly singular potentials, chemotaxis, and active transport
论文作者
论文摘要
本文提供了一个统一的数学分析,对肿瘤生长的非本地扩散界面模型家族描述了由远距离相互作用驱动的演变。这些通过非本地项模型细胞到细胞粘附模型,可以看作是H. Garcke等人提出的相应局部模型的非本地变体。 (2016)。该模型在考虑夫妻夫妻中,肿瘤相变量的非本地Cahn-Hilliard方程具有养分浓度的反应扩散方程,并考虑了重要机制,例如趋化性和主动转运。该系统取决于两个弛豫参数:化学势对粘度系数和抛物线定制系数。本文的第一部分致力于通过两个正规化对系统进行分析。在这里,提出了丰富的结果。首先解决了较弱的适应能力,还包括奇异的电位。然后,在适当的条件下,证明了享有分离财产的强大解决方案的存在。这还允许就数据(包括趋化性和主动转运)获得精致的稳定性估计。本文的第二部分致力于研究系统的渐近行为,因为弛豫参数消失了。当参数分别接近零和共同接近零时,并获得了确切的误差估计值时,分析了渐近性。作为副产品,建立了相应极限系统的适当性。
This paper provides a unified mathematical analysis of a family of non-local diffuse interface models for tumor growth describing evolutions driven by long-range interactions. These integro-partial differential equations model cell-to-cell adhesion by a non-local term and may be seen as non-local variants of the corresponding local model proposed by H. Garcke et al. (2016). The model in consideration couples a non-local Cahn-Hilliard equation for the tumor phase variable with a reaction-diffusion equation for the nutrient concentration, and takes into account also significant mechanisms such as chemotaxis and active transport. The system depends on two relaxation parameters: a viscosity coefficient and parabolic-regularization coefficient on the chemical potential. The first part of the paper is devoted to the analysis of the system with both regularizations. Here, a rich spectrum of results is presented. Weak well-posedness is first addressed, also including singular potentials. Then, under suitable conditions, existence of strong solutions enjoying the separation property is proved. This allows also to obtain a refined stability estimate with respect to the data, including both chemotaxis and active transport. The second part of the paper is devoted to the study of the asymptotic behavior of the system as the relaxation parameters vanish. The asymptotics are analyzed when the parameters approach zero both separately and jointly, and exact error estimates are obtained. As a by-product, well-posedness of the corresponding limit systems is established.