论文标题
活性凝胶中无运动收缩性
Motor-free Contractility in Active Gels
论文作者
论文摘要
动物细胞形成收缩结构，以促进从细胞运动到细胞分裂的各种功能。这些结构中的力产生通常是由于分子电机（例如肌球蛋白）需要极性底物的功能。在这里，我们提出了一种无电机机制，该机制可以在无需极性的情况下在生物聚合物网络中产生收缩。该机制是基于交联的主动结合/解开，该交联链破坏了详细平衡的原理，以及半辅助生物聚合物的不对称力扩展响应。我们发现，这两种成分可以通过非热，类似棘轮的过程产生稳态收缩。我们使用粗粒和微观模型来计算产生的力 - 速度关系。
Animal cells form contractile structures to promote various functions, from cell motility to cell division. Force generation in these structures is often due to molecular motors such as myosin that require polar substrates for their function. Here, we propose a motor-free mechanism that can generate contraction in biopolymer networks without the need for polarity. This mechanism is based on active binding/unbinding of crosslinkers that breaks the principle of detailed balance, together with the asymmetric force-extension response of semiflexible biopolymers. We find that these two ingredients can generate steady state contraction via a non-thermal, ratchet-like process. We calculate the resulting force-velocity relation using both coarse-grained and microscopic models.
