论文标题
结核分枝杆菌基因调控的S系统模型的结构特性
Structural Properties of an S-system Model of Mycobacterium Tuberculosis Gene Regulation
论文作者
论文摘要
2013年，Magombedze和Mulder研究了结核分枝杆菌（MTB）的基因调节系统，通过将其根据推定的基因功能和在休眠/潜伏期发展中的作用将其划分为三个子系统。每个子系统以S-System的形式由嵌入式化学反应网络（CRN）表示，该系统由物种子集和由子系统的Digraph顶点诱导的反应子集定义。对于S-System的嵌入式网络，我们显示出有趣的结构特性，并证明所有S系统CRN（至少有两个物种）都是不一致的。将子系统分析为子网，其中保留了属于不同子系统的顶点之间的弧形，我们形成了从相应的子网络到嵌入式网络的Digraph同态。最后，我们在Digraph的背景下探索了CRN的模块化概念。
Magombedze and Mulder in 2013 studied the gene regulatory system of Mycobacterium Tuberculosis (Mtb) by partitioning this into three subsystems based on putative gene function and role in dormancy/latency development. Each subsystem, in the form of S-system, is represented by an embedded chemical reaction network (CRN), defined by a species subset and a reaction subset induced by the set of digraph vertices of the subsystem. For the embedded networks of S-system, we showed interesting structural properties and proved that all S-system CRNs (with at least two species) are discordant. Analyzing the subsystems as subnetworks, where arcs between vertices belonging to different subsystems are retained, we formed a digraph homomorphism from the corresponding subnetworks to the embedded networks. Lastly, we explored the modularity concept of CRN in the context of digraph.
