论文标题
模拟复杂几何形状中的纤毛驱动的混合和运输
Simulating cilia-driven mixing and transport in complex geometries
论文作者
论文摘要
纤毛和鞭毛是在许多细胞表面上存在的自动锻炼的基于微管的结构，从单细胞生物的外表面到较大动物的内皮表面。一种快速且稳健的数值方法，该方法模拟纤毛的耦合流体动力学和流体中的组成颗粒（例如刚性颗粒，滴或细胞）对于不仅可以理解几种由于纤毛功能障碍而引起的几种疾病和发育性病理，还可以通过固定培养物进行胶状培养物的含量培养物或均具有均匀的层次的含量。在本文中，我们开发了一种混合数值方法，该方法采用边界积分方法来处理限制几何形状和组成型刚性颗粒以及正则stokeslets的方法来处理纤毛。我们提供了几个例子，证明了限制几何形状对纤毛生成的液体混合以及纤毛粒子流体动力学的影响。
Cilia and flagella are self-actuated microtubule-based structures that are present on many cell surfaces, ranging from the outer surface of single-cell organisms to the internal epithelial surfaces in larger animals. A fast and robust numerical method that simulates the coupled hydrodynamics of cilia and the constituent particles in the fluid such as rigid particles, drops or cells would be useful to not only understand several disease and developmental pathologies due to ciliary dysfunction but also to design microfluidic chips with ciliated cultures for some targeted functionality---e.g., maximizing fluid transport or particle mixing. In this paper, we develop a hybrid numerical method that employs a boundary integral method for handling the confining geometries and the constituent rigid particles and the method of regularized Stokeslets for handling the cilia. We provide several examples demonstrating the effects of confining geometries on cilia-generated fluid mixing as well as the cilia-particle hydrodynamics.
